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Clinical Trial
. 2006 Dec;95(12):1694-6.
doi: 10.1080/08035250600764800.

Clarithromycin treatment and QT prolongation in childhood

Ioannis Germanakis  1 , Emmanouil Galanakis, Fragiskos Parthenakis, Panos E Vardas, Maria Kalmanti
Affiliations
Clinical Trial

Clarithromycin treatment and QT prolongation in childhood

Ioannis Germanakis et al. Acta Paediatr. 2006 Dec.

Abstract

The effect of clarithromycin on the QT interval was studied in a group of 28 children treated for respiratory tract infections. QTc was measured before and following 24 h of treatment. A modest (average 22 ms, 95% CI 14-30 ms) but significant QTc prolongation (p<0.001) was observed, with seven cases having a QTc >440 ms during treatment (including a single case with QTc >460 ms).

Conclusion: Serial QTc measurements are necessary for early detection of children at risk for drug-induced arrhythmias.

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