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. 2006 Nov 28;12(44):7161-4.
doi: 10.3748/wjg.v12.i44.7161.

Relationship between Crohn's disease, infection with Mycobacterium avium subspecies paratuberculosis and SLC11A1 gene polymorphisms in Sardinian patients

Leonardo-A Sechi  1 , Maria Gazouli, Lee-E Sieswerda, Paola Molicotti, Niyaz Ahmed, John Ikonomopoulos, Antonio-M Scanu, Daniela Paccagnini, Stefania Zanetti
Affiliations

Relationship between Crohn's disease, infection with Mycobacterium avium subspecies paratuberculosis and SLC11A1 gene polymorphisms in Sardinian patients

Leonardo-A Sechi et al. World J Gastroenterol. .

Abstract

Aim: To study the association between Crohn's disease (CD), Mycobacterium avium subspecies paratuberculosis (MAP), and genetic factors by examining the role of natural resistance-associated macrophage protein 1 (NRAMP1) gene polymorphisms (now SLC11A1) in Sardinian patients with CD and controls.

Methods: Thirty-seven CD patients and 34 controls with no inflammatory bowel disease (IBD) were recruited at the University of Sassari after giving written consent. Six SCL11A1 polymorphisms previously reported to be the most significantly associated with IBD were searched. M. paratuberculosis was identified by IS900 PCR and sequencing. Logistic regression was used to calculate odds ratios (OR) for the associations among CD, presence of MAP, and 6 loci described above.

Results: For the first time, a strong association was observed between polymorphisms at NRAMP1 locus 823C/T and CD. While CD was strongly associated with both NRAMP1 and MAP, NRAMP1 polymorphisms and MAP themselves were not correlated.

Conclusion: Combined with previous work on the NOD2/CARD15 gene, it is clear that the interplay of genetic, infectious, and immunologic factors in the etiology of CD is complex.

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Figures

Figure 1
Figure 1
Actual probability of CD and predicted probability of CD showing strong independent effects of MAP infection and each of the loci on the probability of CD.
See this image and copyright information in PMC

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References

    1. Canonne-Hergaux F, Gruenheid S, Govoni G, Gros P. The Nramp1 protein and its role in resistance to infection and macrophage function. Proc Assoc Am Physicians. 1999;111:283–289. - PubMed
    1. Blackwell JM, Barton CH, White JK, Searle S, Baker AM, Williams H, Shaw MA. Genomic organization and sequence of the human NRAMP gene: identification and mapping of a promoter region polymorphism. Mol Med. 1995;1:194–205. - PMC - PubMed
    1. Blackwell JM, Searle S. Genetic regulation of macrophage activation: understanding the function of Nramp1 (=Ity/Lsh/Bcg) Immunol Lett. 1999;65:73–80. - PubMed
    1. Bellamy R. Susceptibility to mycobacterial infections: the importance of host genetics. Genes Immun. 2003;4:4–11. - PubMed
    1. Ferreira FR, Goulart LR, Silva HD, Goulart IM. Susceptibility to leprosy may be conditioned by an interaction between the NRAMP1 promoter polymorphisms and the lepromin response. Int J Lepr Other Mycobact Dis. 2004;72:457–467. - PubMed

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