In vitro neutralization of Chlamydia trachomatis by monovalent Fab antibody specific to the major outer membrane protein
- PMID: 1713202
- PMCID: PMC258096
- DOI: 10.1128/iai.59.8.2843-2845.1991
In vitro neutralization of Chlamydia trachomatis by monovalent Fab antibody specific to the major outer membrane protein
Abstract
Monovalent Fab antibodies to serovar- and subspecies-specific epitopes of the major outer membrane protein (MOMP) of Chlamydia trachomatis neutralized infectivity for hamster kidney cells by preventing chlamydial attachment. These findings exclude the aggregation of chlamydiae as a mechanism of anti-MOMP neutralization and provide additional evidence in support of the MOMP as a chlamydial adhesin.
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