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Review
. 2006 Dec;58(4):712-25.
doi: 10.1124/pr.58.4.4.

International Union of Pharmacology. LX. Retinoic acid receptors

Pierre Germain  1 , Pierre Chambon, Gregor Eichele, Ronald M Evans, Mitchell A Lazar, Mark Leid, Angel R De Lera, Reuben Lotan, David J Mangelsdorf, Hinrich Gronemeyer
Affiliations
Review

International Union of Pharmacology. LX. Retinoic acid receptors

Pierre Germain et al. Pharmacol Rev. 2006 Dec.

Abstract

Retinoid is a term for compounds that bind to and activate retinoic acid receptors (RARalpha, RARbeta, and RARgamma), members of the nuclear hormone receptor superfamily. The most important endogenous retinoid is all-trans-retinoic acid. Retinoids regulate a wide variety of essential biological processes, such as vertebrate embryonic morphogenesis and organogenesis, cell growth arrest, differentiation and apoptosis, and homeostasis, as well as their disorders. This review summarizes the considerable amount of knowledge generated on these receptors.

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