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. 2007 Jan;29(1):79-83.
doi: 10.1016/j.ijantimicag.2006.08.025. Epub 2006 Nov 28.

Effect of antifungal treatment in a murine model of blastoschizomycosis

Carolina Serena  1 , Marçal Mariné, Rita Marimon, Francisco Javier Pastor, Josep Guarro
Affiliations

Effect of antifungal treatment in a murine model of blastoschizomycosis

Carolina Serena et al. Int J Antimicrob Agents. 2007 Jan.

Abstract

Blastoschizomyces capitatus is an emerging pathogenic fungus that can cause deep invasive diseases in neutropenic patients. We developed a model of disseminated blastoschizomycosis in immunosuppressed mice to evaluate the effectiveness of amphotericin B, flucytosine, fluconazole and voriconazole. High-dose fluconazole was the most effective drug at prolonging the survival of mice and at reducing fungal burden in the kidneys, spleen and liver.

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