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. 2006 Fall;18(4):509-15.
doi: 10.1176/jnp.2006.18.4.509.

Aggression and quantitative MRI measures of caudate in patients with chronic schizophrenia or schizoaffective disorder

Matthew J Hoptman  1 , Jan Volavka, Pál Czobor, Guido Gerig, Miranda Chakos, Joseph Blocher, Leslie L Citrome, Brain Sheitman, Jean-Pierre Lindenmayer, Jeffrey A Lieberman, Robert M Bilder
Affiliations

Aggression and quantitative MRI measures of caudate in patients with chronic schizophrenia or schizoaffective disorder

Matthew J Hoptman et al. J Neuropsychiatry Clin Neurosci. 2006 Fall.

Abstract

Caudate dysfunction is implicated in schizophrenia. However, little is known about the relationship between aggression and caudate volumes. Forty-nine patients received magnetic resonance imaging scanning in a double-blind treatment study in which aggression was measured. Caudate volumes were computed using a semiautomated method. The authors measured aggression with the Overt Aggression Scale and the Positive and Negative Syndrome Scale. Larger caudate volumes were associated with greater levels of aggression. The relationship between aggression and caudate volumes may be related to the iatrogenic effects of long-term treatment with typical antipsychotic agents or to a direct effect of schizophrenic processes on the caudate.

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Figures

FIGURE 1
FIGURE 1
(Left) Axial (upper left), Sagittal (upper right), and Coronal (bottom right) Views of the Segmented Brain. (Right) Enlargement of Rendered Caudate Volumes
See this image and copyright information in PMC

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