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Clinical Trial
. 2007 Feb;45(2):627-30.
doi: 10.1128/JCM.00816-06. Epub 2006 Nov 29.

The sensitivity of the OptiMAL rapid diagnostic test to the presence of Plasmodium falciparum gametocytes compromises its ability to monitor treatment outcomes in an area of Papua New Guinea in which malaria is endemic

Ivo Mueller  1 , Inoni Betuela, Meza Ginny, John C Reeder, Blaise Genton
Affiliations
Clinical Trial

The sensitivity of the OptiMAL rapid diagnostic test to the presence of Plasmodium falciparum gametocytes compromises its ability to monitor treatment outcomes in an area of Papua New Guinea in which malaria is endemic

Ivo Mueller et al. J Clin Microbiol. 2007 Feb.

Abstract

Using in vivo samples from treatment failure malaria cases, we demonstrate the high sensitivity of the parasite lactase dehydrogenase (pLDH)-based OptiMAL rapid diagnostic test in the detection of P. falciparum gametocytes. This high sensitivity limits the use of pLDH-based tests in the monitoring of treatment outcomes in circumstances where gametocytemia is common.

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References

    1. Cooke, A. H., P. L. Chiodini, T. Doherty, A. H. Moody, J. Ries, and M. Pinder. 1999. Comparison of a parasite lactate dehydrogenase-based immunochromatographic antigen detection assay (OptiMAL) with microscopy for the detection of malaria parasites in human blood samples. Am. J. Trop. Med. Hyg. 60:173-176. - PubMed
    1. Craig, M. H., B. L. Bredenkamp, C. H. Williams, E. J. Rossouw, V. J. Kelly, I. Kleinschmidt, A. Martineau, and G. F. Henry. 2002. Field and laboratory comparative evaluation of ten rapid malaria diagnostic tests. Trans. R. Soc. Trop. Med. Hyg. 96:258-265. - PubMed
    1. Genton, B., I. Mueller, I. Betuela, G. Casey, M. Ginny, M. P. Alpers, and J. C. Reeder. 2006. Rifampicin/cotrimoxazole/isoniazid versus mefloquine or quinine + sulfadoxine-pyrimethamine for malaria: a randomized trial. PLoS Clin. Trials 1:e38. doi:10.1371/journal.pctr.0010038. - DOI - PMC - PubMed
    1. Grobusch, M. P., T. Hanscheid, K. Gobels, H. Slevogt, T. Zoller, G. Rogler, and D. Teichmann. 2003. Comparison of three antigen detection tests for diagnosis and follow-up of falciparum malaria in travellers returning to Berlin, Germany. Parasitol. Res. 89:354-357. - PubMed
    1. Huong, N. M., T. M. Davis, S. Hewitt, N. V. Huong, T. T. Uyen, D. H. Nhan, and L. D. Cong. 2002. Comparison of three antigen detection methods for diagnosis and therapeutic monitoring of malaria: a field study from southern Vietnam. Trop. Med. Int. Health 7:304-308. - PubMed

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