doi: 10.1196/annals.1373.024.
SEPPIC vaccine adjuvants for poultry
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- PMID: 17135512
- DOI: 10.1196/annals.1373.024
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SEPPIC vaccine adjuvants for poultry
Ann N Y Acad Sci.
2006 Oct.
Abstract
Two inactivated antigens (Newcastle and Pasteurella Multocida) were formulated with different adjuvants and tested in two separate experiments in poultry. Oil formulations constituting water in oil (W/O) or water in oil in water (W/O/W) emulsions were assessed for antibody response, protection, local reactions, and vaccine physicochemical parameters. Robust, efficacious, and safe formulations were obtained with W/O formulations whereas W/O/W was especially safe with maintained efficacy. Results show that it is possible to improve traditional Tween Span formulations for safety and efficacy parameters by using Montanide ISA 70 for W/O formulations and Montanide ISA 206 for W/O/W when safety is the priority.
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