The use of wireless laptop computers for computer-assisted learning in pharmacokinetics

Abstract

Objective: To implement computer-assisted learning workshops into pharmacokinetics courses in a doctor of pharmacy (PharmD) program.

Design: Workshops were designed for students to utilize computer software programs on laptop computers to build pharmacokinetic models to predict drug concentrations resulting from various dosage regimens. In addition, students were able to visualize through graphing programs how altering different parameters changed drug concentration-time curves. Surveys were conducted to measure students' attitudes toward computer technology before and after implementation. Finally, traditional examinations were used to evaluate student learning.

Assessment: Doctor of pharmacy students responded favorably to the use of wireless laptop computers in problem-based pharmacokinetic workshops. Eighty-eight percent (n = 61/69) and 82% (n = 55/67) of PharmD students completed surveys before and after computer implementation, respectively. Prior to implementation, 95% of students agreed that computers would enhance learning in pharmacokinetics. After implementation, 98% of students strongly agreed (p < 0.05) that computers enhanced learning. Examination results were significantly higher after computer implementation (89% with computers vs. 84% without computers; p = 0.01).

Conclusion: Implementation of wireless laptop computers in a pharmacokinetic course enabled students to construct their own pharmacokinetic models that could respond to changing parameters. Students had greater comprehension and were better able to interpret results and provide appropriate recommendations. Computer-assisted pharmacokinetic techniques can be powerful tools when making decisions about drug therapy.

Figure 1

Mexiletine concentration-time curves in poor, intermediate, and extensive CYP2D6 metabolizers. (Mexiletine, 200 mg, administered PO q 8 hrs; therapeutic concentration, 0.5 – 2.0 mg/L; toxic concentration, 1.5 -2.0 mg/L)