Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2006 Sep;6(3):177-81.
doi: 10.5555/afhs.2006.6.3.177.

Abnormal haemoglobin variants, ABO and Rh blood groups among student of African descent in Port Harcourt, Nigeria

Zaccheaus Awortu Jeremiah  1
Affiliations

Abnormal haemoglobin variants, ABO and Rh blood groups among student of African descent in Port Harcourt, Nigeria

Zaccheaus Awortu Jeremiah. Afr Health Sci. 2006 Sep.

Abstract

Background: Abnormal haemoglobin variants (HbSS,AS,AC,SC,etc) have been known to be common among blacks. Patients with sickle cell disease are often faced with the risk of alloimmunization from allogeneic blood transfusion.

Objectives: The study was designed to sample students population of African descents for the purpose of updating information on the prevalence of abnormal haemoglobin variants, ABO, and Rh blood groups and compare the results with previously published data.

Methods: Standard electrophoretic and haemagglutination techniques were employed in testing the blood samples.

Results: Of the 620 students screened, 80.32% were HbAA and 19.68% HbAS. 22.9% were of blood group A, 17.10% group B, 4.84% group AB and 55.16% group O. 96.77% were Rh.D positive while 3.23% were Rh D negative. Sickle cell gene in homozygous state (HbSS) and other abnormal haemoglobin variants were not encountered in this students population,. Analysis of the students population revealed that 454(73.23%) were females while 166(26.77%) were males. Participants of the age group 26-30 years (35.7%) constituted the majority and in this age group, all blood groups were represented.

Conclusion: There is a gradual decline in the prevalence of abnormal haemoglobin variants in our black population. The frequencies of ABO and Rh blood groups however appeared to be stable and consistent with previous published data.

PubMed Disclaimer

Figures

Figure 1
Figure 1
Frequencies of male and female students according to their age groups
Figure 2
Figure 2
Distribution of ABO and Rh blood groups among different age groups.
Figure 3
Figure 3
Distribution of haemoglobin genotypes among students in relation to their age groups.
See this image and copyright information in PMC

References

    1. Weatheral DJ. Genetic disorders of haemogloobin. In: Hoffbrand AV, Lewis SM, Tuddenham EGD, editors. Postgraduate haematology. 4th ed. London, UK: Arnold Publishers; 2001. pp. 91–119.
    1. Okpala I, Thomas V, Westerdale N, Jegede T, Raj K, Daley S, Costello - Binger H, Mullen J, Rochester - Peart C, Helps C, Tulloch E, Akpala M, Dick M, Bewley S, Davies M, Abbs I. The comprehensive care of sickle cell disease. Eur J Haematol. 2002;68(3):157–162. - PubMed
    1. Pramanik T, Pramanik S. Distribution of ABO and Rh blood groups in Nepalese Medical Students: a report. East Mediterr Health J. 2000;6(1):156–158. - PubMed
    1. Conteras M, Lubenko A. Immunohaematology: Introduction. In: Hoffbrand AV, Lewis SM, Tuddenham EGD, editors. Postgraduate haematology. 4th ed. London UK: Arnold Publishers; 2001. pp. 165–181.
    1. Knowles S, Poole G. Human blood group systems. In: Murphy MF, Pamphilon DH, editors. Practical transfusion medicine. 1st ed. London, UK: Blackwell Science; 2002. pp. 24–31.

LinkOut - more resources