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. 2007 Jan;35(Database issue):D363-6.
doi: 10.1093/nar/gkl970. Epub 2006 Nov 16.

euHCVdb: the European hepatitis C virus database

Christophe Combet  1 , Nicolas Garnier, Céline Charavay, Delphine Grando, Daniel Crisan, Julien Lopez, Alexandre Dehne-Garcia, Christophe Geourjon, Emmanuel Bettler, Chantal Hulo, Philippe Le Mercier, Ralf Bartenschlager, Helmut Diepolder, Darius Moradpour, Jean-Michel Pawlotsky, Charles M Rice, Christian Trépo, François Penin, Gilbert Deléage
Affiliations

euHCVdb: the European hepatitis C virus database

Christophe Combet et al. Nucleic Acids Res. 2007 Jan.

Abstract

The hepatitis C virus (HCV) genome shows remarkable sequence variability, leading to the classification of at least six major genotypes, numerous subtypes and a myriad of quasispecies within a given host. A database allowing researchers to investigate the genetic and structural variability of all available HCV sequences is an essential tool for studies on the molecular virology and pathogenesis of hepatitis C as well as drug design and vaccine development. We describe here the European Hepatitis C Virus Database (euHCVdb, http://euhcvdb.ibcp.fr), a collection of computer-annotated sequences based on reference genomes. The annotations include genome mapping of sequences, use of recommended nomenclature, subtyping as well as three-dimensional (3D) molecular models of proteins. A WWW interface has been developed to facilitate database searches and the export of data for sequence and structure analyses. As part of an international collaborative effort with the US and Japanese databases, the European HCV Database (euHCVdb) is mainly dedicated to HCV protein sequences, 3D structures and functional analyses.

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Figures

Figure 1
Figure 1
An overview of euHCVdb. (A) A static page describing known data for NS3 protein. (B) The multiple sequence alignment of NS3 protein from (A) viewed in the EditAlignment applet. (C) A query result page with the display and tools boxes, and list of hits. (D) An entry details page, with data for NS3 and links to the euHCVdb3D models. (E) A molecular model viewed through the euHCVdb3D interface. The Jmol applet is linked with the alignment between the modeled and template PDB sequences.
See this image and copyright information in PMC

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