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Randomized Controlled Trial
. 2006 Dec 16;333(7581):1241.
doi: 10.1136/bmj.39010.581354.55. Epub 2006 Dec 1.

Effectiveness of an influenza vaccine programme for care home staff to prevent death, morbidity, and health service use among residents: cluster randomised controlled trial

Andrew C Hayward  1 , Richard Harling, Sally Wetten, Anne M Johnson, Susan Munro, Julia Smedley, Shahed Murad, John M Watson
Affiliations
Randomized Controlled Trial

Effectiveness of an influenza vaccine programme for care home staff to prevent death, morbidity, and health service use among residents: cluster randomised controlled trial

Andrew C Hayward et al. BMJ. .

Abstract

Objective: To determine whether vaccination of care home staff against influenza indirectly protects residents.

Design: Pair matched cluster randomised controlled trial.

Setting: Large private chain of UK care homes during the winters of 2003-4 and 2004-5.

Participants: Nursing home staff (n=1703) and residents (n=2604) in 44 care homes (22 intervention homes and 22 matched control homes).

Interventions: Vaccination offered to staff in intervention homes but not in control homes.

Main outcome measures: The primary outcome was all cause mortality of residents. Secondary outcomes were influenza-like illness and health service use in residents.

Results: In 2003-4 vaccine coverage in full time staff was 48.2% (407/884) in intervention homes and 5.9% (51/859) in control homes. In 2004-5 uptake rates were 43.2% (365/844) and 3.5% (28/800). National influenza rates were substantially below average in 2004-5. In the 2003-4 period of influenza activity significant decreases were found in mortality of residents in intervention homes compared with control homes (rate difference -5.0 per 100 residents, 95% confidence interval -7.0 to -2.0) and in influenza-like illness (P=0.004), consultations with general practitioners for influenza-like illness (P=0.008), and admissions to hospital with influenza-like illness (P=0.009). No significant differences were found in 2004-5 or during periods of no influenza activity in 2003-4.

Conclusions: Vaccinating care home staff against influenza can prevent deaths, health service use, and influenza-like illness in residents during periods of moderate influenza activity.

Trial registration: National Research Register N0530147256.

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Conflict of interest statement

Competing interests: None declared.

Figures

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Fig 1 Royal College of General Practitioners' consultation rate for influenza-like illness (consultations per 100 000 population) and periods of influenza activity
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Fig 2 Participant flow
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