Ab initio investigations on the intermediates of RNA cleaving processes
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- PMID: 1714570
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Ab initio investigations on the intermediates of RNA cleaving processes
Nucleic Acids Symp Ser.
1990.
Abstract
Ab initio molecular orbital calculations have been carried out on acyclic oxyphosphoranes in order to elucidate the origin of previously calculated energy differences of cyclic counterparts of RNA cleaving reactions. It appears that the orientation of the equatorial methoxyl group has pronounced effects in energy on the transition states than the metastable intermediates.