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Comment
. 2006 Dec 12;103(50):18879-80.
doi: 10.1073/pnas.0609522103. Epub 2006 Dec 4.

Flavivirus nonstructural protein NS1: complementary surprises

Jacob J Schlesinger  1
Affiliations
Comment

Flavivirus nonstructural protein NS1: complementary surprises

Jacob J Schlesinger. Proc Natl Acad Sci U S A. .
No abstract available

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Conflict of interest statement

The author declares no conflict of interest.

Figures

Fig. 1.
Fig. 1.
Possible effects of cell surface NS1-complexed fH on alternative complement pathway (AP) activation. (Box 1) The normal AP amplification loop. Interactions between cell surface-bound C3b, fB, and protease factor D generate the C3bBb convertase that amplifies C3b production, which finally leads to C5b-9 membrane attack complex (MAC) formation and cell membrane damage. (Box 2) Recruitment of fH by NS1 disrupts C3bBb convertase assembly and function. (Box 3) In addition, fH, acting with protease fI, cleaves cell surface-bound C3b to produce the functionally inactivated form of C3b, iC3b. The net result of events in boxes 2 and 3 is inhibition of MAC formation. (A comprehensive summary of alternative complement pathway activation is found in ref. .)
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