Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Randomized Controlled Trial
. 2006 Dec 5:6:274.
doi: 10.1186/1471-2407-6-274.

Quality of life in patients with advanced gastric cancer: a randomized trial comparing docetaxel, cisplatin, 5-FU (TCF) with epirubicin, cisplatin, 5-FU (ECF)

Sanambar Sadighi  1 , Mohammad Ali Mohagheghi, Ali Montazeri, Zahra Sadighi
Affiliations
Randomized Controlled Trial

Quality of life in patients with advanced gastric cancer: a randomized trial comparing docetaxel, cisplatin, 5-FU (TCF) with epirubicin, cisplatin, 5-FU (ECF)

Sanambar Sadighi et al. BMC Cancer. .

Abstract

Background: Health related quality of life (HRQOL) is an important outcome after treatment for upper gastrointestinal carcinoma. This study aimed to compare HRQOL in patients with advanced gastric cancer (GC) receiving either a standard or an experimental treatment.

Methods: Seventy-one patients have been treated in Cancer Institute (Tehran, Iran) with docetaxel, cisplatin, 5 FU (TCF) or epirubicin, cisplatin, 5-FU (ECF) and were followed from Jan 2002 to Jan 2005. End points were response rate, HRQOL and survival. HRQOL was assessed using the EORCT QLQ-C30 at baseline and after the third cycle of chemotherapy.

Results: The baseline HRQOL scores were comparable between two groups. After treatment improvement was seen in a number of items and domains except for cognitive functioning, and diarrhoea. Pain decreased and physical functioning improved in both groups. However, only the TCF group showed statistically and clinically meaningful improvement in global QOL (P = 0.001). Surgical and pathologic response was better with TCF but there was no difference in survival rate between two groups.

Conclusion: Docetaxel based treatment (TCF) showed better palliation and improvement of global QOL as compared with epirubicin based treatment (ECF). However, it seems that regardless of treatment offered, effective chemotherapy was the most important factor affecting QOL in these patients.

PubMed Disclaimer

Figures

Figure 1
Figure 1
Follow-up global quality of life scores in responding and not responding patients for each treatment group (Higher values show better global quality of life): ECF: Mean score (SD); Responding 63.5 (14.2), Not responding 54.2 (14.9). TCF: Mean score (SD); Responding 63.3 (16.6), Not responding 48.8 (13.5).
See this image and copyright information in PMC

References

    1. Kaptein AA, Morita S, Sakamoto J. Quality of life in gastric cancer. World J Gastroenterol. 2005;11:3189–3196. - PMC - PubMed
    1. Blazeby JM, Nicklin J, Brookes ST, Winstone K, Alderson D. Feasibility of quality of life assessment in patients with upper gastrointestinal tract cancer. Br J Cancer. 2003;89:497–501. doi: 10.1038/sj.bjc.6601146. - DOI - PMC - PubMed
    1. Blazeby JM. The role of quality of life assessment in gastric cancer. Jpn J Clin Oncol. 2000;30:246. doi: 10.1093/jjco/30.5.246. - DOI - PubMed
    1. Park SH, Lee WK, Chung M, Bang SM, Cho EK, Lee JH, Shin DB. Quality of life in patients with advanced gastric cancer treated with second-line chemotherapy. Cancer Chemother Pharmacol. 2006;57:289–294. doi: 10.1007/s00280-005-0055-y. - DOI - PubMed
    1. Sadighi S, Mohagheghi MA, Meemari F. Randomized clinical trial comparing docetaxel, cisplatin, 5-FU (TCF) with epirubicin, cisplatin, 5-FU in advanced gastric adenocarcinoma. J of Med Faculty of Tehran University of Medical Sciences. [in Persian]

Publication types

MeSH terms

Supplementary concepts