Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2006 Dec 22;2(4):604-7.
doi: 10.1098/rsbl.2006.0521.

Contrasting patterns of sequence divergence and base composition between Drosophila introns and intergenic regions

Lino Ometto  1 , David De Lorenzo, Wolfgang Stephan
Affiliations

Contrasting patterns of sequence divergence and base composition between Drosophila introns and intergenic regions

Lino Ometto et al. Biol Lett. .

Abstract

Two non-coding DNA classes, introns and intergenic regions, of Drosophila melanogaster exhibit contrasting evolutionary patterns. GC content is significantly higher in intergenic regions and affects their degree of nucleotide variability. Divergence is positively correlated with recombination rate in intergenic regions, but not in introns. We argue that these differences are due to different selective constraints rather than mutational or recombinational mechanisms.

PubMed Disclaimer

Figures

Figure 1
Figure 1
Correlation between divergence from D. yakuba and recombination rate (expressed in recombination events per site per generation; Comeron et al. 1999).
See this image and copyright information in PMC

Similar articles

See all similar articles

Cited by

See all "Cited by" articles

References

    1. Akashi H. Molecular evolution between Drosophila melanogaster and D. simulans: reduced codon bias, faster rates of amino acid substitution, and larger proteins in D. melanogaster. Genetics. 1996;144:1297–1307. - PMC - PubMed
    1. Andolfatto P. Adaptive evolution of non-coding DNA in Drosophila. Nature. 2005;437:1149–1152. doi: 10.1038/nature04107 - DOI - PubMed
    1. Chen Y, Stephan W. Weak selection on noncoding gene features. In: Fox C.W, Wolf J.B, editors. Evolutionary genetics—concepts and case studies. Oxford University Press; Oxford, UK: 2006. pp. 133–143.
    1. Comeron J.M, Kreitman M, Aguadé M. Natural selection on synonymous sites is correlated with gene length and recombination in Drosophila. Genetics. 1999;151:239–249. - PMC - PubMed
    1. Galtier N, Bazin E, Bierne N. GC-biased segregation of non-coding polymorphisms in Drosophila. Genetics. 2006;172:221–228. doi:10.1534/genetics.105.046524 - DOI - PMC - PubMed

Publication types

Substances

LinkOut - more resources