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. 2006 Dec 22;2(4):604-7.
doi: 10.1098/rsbl.2006.0521.

Contrasting patterns of sequence divergence and base composition between Drosophila introns and intergenic regions

Lino Ometto  1 , David De Lorenzo, Wolfgang Stephan
Affiliations

Contrasting patterns of sequence divergence and base composition between Drosophila introns and intergenic regions

Lino Ometto et al. Biol Lett. .

Abstract

Two non-coding DNA classes, introns and intergenic regions, of Drosophila melanogaster exhibit contrasting evolutionary patterns. GC content is significantly higher in intergenic regions and affects their degree of nucleotide variability. Divergence is positively correlated with recombination rate in intergenic regions, but not in introns. We argue that these differences are due to different selective constraints rather than mutational or recombinational mechanisms.

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Figures

Figure 1
Figure 1
Correlation between divergence from D. yakuba and recombination rate (expressed in recombination events per site per generation; Comeron et al. 1999).
See this image and copyright information in PMC

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