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. 2007 Jan;35(Database issue):D857-62.
doi: 10.1093/nar/gkl1006. Epub 2006 Dec 5.

AthaMap web tools for the analysis and identification of co-regulated genes

Claudia Galuschka  1 , Martin Schindler, Lorenz Bülow, Reinhard Hehl
Affiliations

AthaMap web tools for the analysis and identification of co-regulated genes

Claudia Galuschka et al. Nucleic Acids Res. 2007 Jan.

Abstract

The AthaMap database generates a map of cis-regulatory elements for the whole Arabidopsis thaliana genome. This database has been extended by new tools to identify common cis-regulatory elements in specific regions of user-provided gene sets. A resulting table displays all cis-regulatory elements annotated in AthaMap including positional information relative to the respective gene. Further tables show overviews with the number of individual transcription factor binding sites (TFBS) present and TFBS common to the whole set of genes. Over represented cis-elements are easily identified. These features were used to detect specific enrichment of drought-responsive elements in cold-induced genes. For identification of co-regulated genes, the output table of the colocalization function was extended to show the closest genes and their relative distances to the colocalizing TFBS. Gene sets determined by this function can be used for a co-regulation analysis in microarray gene expression databases such as Genevestigator or PathoPlant. Additional improvements of AthaMap include display of the gene structure in the sequence window and a significant data increase. AthaMap is freely available at http://www.athamap.de/.

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Figures

Figure 1
Figure 1
Partial screenshot of a Gene Analysis result page. Only the first lines of the result table showing common binding sites in the gene set are displayed.
See this image and copyright information in PMC

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