Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Comment
. 2006 Dec;169(6):1910-2.
doi: 10.2353/ajpath.2006.060923.

Zebrafish as a novel model system to study the function of caveolae and caveolin-1 in organismal biology

Philippe G Frank  1 , Michael P Lisanti
Affiliations
Comment

Zebrafish as a novel model system to study the function of caveolae and caveolin-1 in organismal biology

Philippe G Frank et al. Am J Pathol. 2006 Dec.
No abstract available

PubMed Disclaimer

Figures

Figure 1
Figure 1
Evolutionary conservation of the caveolin-1 (Cav-1) protein. Alignment of the Cav-1 protein sequences from C. elegans (accession no. Q94051), D. rerio (accession no. Q6YLH9), and Homo sapiens (accession no. Q2TNI1) was produced using CINEMA. Note that the β-isoform uses an internal methionine (M32 in humans; M34 in zebrafish) as an initiation codon, as indicated (α versus β). As such, only the α-isoform undergoes tyrosine phosphorylation [Y14 in humans and zebrafish; see asterisk], since the β-isoform lacks tyrosine 14. The positions of the caveolin-signature-sequence (SQ) and the caveolin-scaffolding-domain (CSD) are highlighted. Palmitoylated cysteine residues have been boxed, in the case of the human and zebrafish sequences. Color coding is as follows: white, hydrophobic residues; blue, positively charged residues; red, negatively charged residues; green, small hydrogen bonding residues; brown, glycine/proline residues; yellow, cysteine residues; and cyan, aromatic residues.
See this image and copyright information in PMC

Comment on

References

    1. Glenney JRJ, Soppet D. Sequence and expression of caveolin, a protein component of caveolae plasma membrane domains phosphorylated on tyrosine in Rous sarcoma virus-transformed fibroblasts. Proc Natl Acad Sci USA. 1992;89:10517–10521. - PMC - PubMed
    1. Kurzchalia T, Dupree P, Parton RG, Kellner R, Virta H, Lehnert M, Simons K. VIP 21, a 21-kD membrane protein is an integral component of trans-Golgi-network-derived transport vesicles. J Cell Biol. 1992;118:1003–1014. - PMC - PubMed
    1. Rothberg KG, Heuser JE, Donzell WC, Ying YS, Glenney JR, Anderson RG. Caveolin, a protein component of caveolae membrane coats. Cell. 1992;68:673–682. - PubMed
    1. Drab M, Verkade P, Elger M, Kasper M, Lohn M, Lauterbach B, Menne J, Lindschau C, Mende F, Luft FC, Schedl A, Haller H, Kurzchalia TV. Loss of caveolae, vascular dysfunction, and pulmonary defects in caveolin-1 gene-disrupted mice. Science. 2001;293:2449–2452. - PubMed
    1. Razani B, Engelman JA, Wang XB, Schubert W, Zhang XL, Marks CB, Macaluso F, Russell RG, Li M, Pestell RG, Di Vizio D, Hou H, Jr, Kneitz B, Lagaud G, Christ GJ, Edelmann W, Lisanti MP. Caveolin-1 null mice are viable but show evidence of hyperproliferative and vascular abnormalities. J Biol Chem. 2001;276:38121–38138. - PubMed

Publication types

LinkOut - more resources