Ondansetron treatment in a child presenting with chronic intractable pruritus
- PMID: 17149457
- PMCID: PMC2673141
- DOI: 10.1155/2006/873870
Ondansetron treatment in a child presenting with chronic intractable pruritus
Abstract
The case of a seven-year-old boy with chronic pruritus secondary to a giant congenital melanocytic nevus is presented. The pruritus did not respond to conventional antipruritic drug treatment, but responded to ondansetron, a selective antagonist of 5-hydroxytryptamine type 3 receptors.
Est présenté le cas d’un garçon de sept ans atteint d’un prurit chronique secondaire à un naevus mélanocytique géant congénital. Le prurit n’a pas répondu à un traitement classique aux antipruritiques, mais a répondu à l’ondansétron, un antagoniste sélectif des récepteurs 5-hydroxytryptamine de type 3.
Similar articles
-
Life-threatening blood loss from scratching provoked by pruritus in the bulky perineal nevocytoma variant of giant congenital melanocytic nevus in a child.J Am Acad Dermatol. 2005 Aug;53(2 Suppl 1):S139-42. doi: 10.1016/j.jaad.2004.12.040. J Am Acad Dermatol. 2005. PMID: 16021164
-
Ondansetron for paediatric uraemic pruritus: a case report.Pediatr Nephrol. 2004 Jun;19(6):694-6. doi: 10.1007/s00467-004-1471-7. Epub 2004 Apr 15. Pediatr Nephrol. 2004. PMID: 15085422
-
A controlled trial of ondansetron in the pruritus of cholestasis.Aliment Pharmacol Ther. 2005 Apr 15;21(8):1041-5. doi: 10.1111/j.1365-2036.2005.02430.x. Aliment Pharmacol Ther. 2005. PMID: 15813840 Clinical Trial.
-
Pruritus and fatigue associated with liver disease: is there a role for ondansetron?Expert Opin Pharmacother. 2008 Mar;9(4):645-51. doi: 10.1517/14656566.9.4.645. Expert Opin Pharmacother. 2008. PMID: 18312165 Review.
-
Prophylactic Ondansetron for the Prevention of Intrathecal Fentanyl- or Sufentanil-Mediated Pruritus: A Meta-Analysis of Randomized Trials.Anesth Analg. 2016 Feb;122(2):402-9. doi: 10.1213/ANE.0000000000001046. Anesth Analg. 2016. PMID: 26505578 Review.
Cited by
-
Congenital melanocytic neoplasms: clinical, histopathological and recent molecular developments.Virchows Arch. 2025 Jan;486(1):165-176. doi: 10.1007/s00428-024-04011-3. Epub 2025 Jan 15. Virchows Arch. 2025. PMID: 39810001 Free PMC article. Review. No abstract available.
-
Neurocutaneous melanocytosis (melanosis).Childs Nerv Syst. 2020 Oct;36(10):2571-2596. doi: 10.1007/s00381-020-04770-9. Epub 2020 Oct 13. Childs Nerv Syst. 2020. PMID: 33048248
-
Ondansetron to treat pruritus due to cholestatic jaundice.J Pediatr Pharmacol Ther. 2013 Jul;18(3):241-6. doi: 10.5863/1551-6776-18.3.241. J Pediatr Pharmacol Ther. 2013. PMID: 24052788 Free PMC article.
-
Medication Repurposing in Pediatric Patients: Teaching Old Drugs New Tricks.J Pediatr Pharmacol Ther. 2016 Jan-Feb;21(1):36-53. doi: 10.5863/1551-6776-21.1.36. J Pediatr Pharmacol Ther. 2016. PMID: 26997928 Free PMC article.
References
-
- Koeller JM, Aapro MS, Gralla RJ, et al. Antiemetic guidelines: Creating a more practical treatment approach. Support Care Cancer. 2002;10:519–22. - PubMed
-
- Gan TJ, Meyer T, Apfel CC, et al. Department of Anesthesiology, Duke University Medical Center Consensus guidelines for managing postoperative nausea and vomiting. Anesth Analg. 2003;97:62–71. - PubMed
-
- Tzeng JI, Chu KS, Ho ST, Cheng KI, Liu KS, Wang JJ. Prophylactic iv ondansetron reduces nausea, vomiting and pruritus following epidural morphine for postoperative pain control. Can J Anaesth. 2003;50:1023–6. - PubMed
-
- Charuluxananan S, Kyokong O, Somboonviboon W, Narasethakamol A, Promlok P. Nalbuphine versus ondansetron for prevention of intrathecal morphine-induced pruritus after cesarean delivery. Anesth Analg. 2003;96:1789–93. - PubMed
-
- Borgeat A, Stirnemann HR. Ondansetron is effective to treat spinal or epidural morphine-induced pruritus. Anesthesiology. 1999;90:432–6. - PubMed
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Medical