Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2007;12(2):162-75.
doi: 10.2478/s11658-006-0062-y. Epub 2006 Dec 6.

N-terminal brain natriuretic propeptide levels correlate with procalcitonin and C-reactive protein levels in septic patients

Mariusz Piechota  1 , Maciej Banach, Robert Irzmański, Małgorzata Misztal, Jacek Rysz, Marcin Barylski, Magdalena Piechota-Urbańska, Jan Kowalski, Lucjan Pawlicki
Affiliations

N-terminal brain natriuretic propeptide levels correlate with procalcitonin and C-reactive protein levels in septic patients

Mariusz Piechota et al. Cell Mol Biol Lett. 2007.

Abstract

The aim of this study was to find the relationship between N-terminal brain natriuretic propeptide (NT-proBNP), procalcitonin (PCT) and C-reactive protein (CRP) plasma concentrations in septic patients. This was a prospective study, performed at Medical University Hospital No. 5 in łódź. Twenty patients with sepsis and severe sepsis were included in the study. N-terminal brain natriuretic propeptide, procalcitonin and C-reactive protein concentrations, and survival were evaluated. In the whole studied group (128 measurements), the mean NT-proBNP, procalcitonin and C-reactive protein concentrations were, respectively: 140.80+/-84.65 pg/ml, 22.32+/-97.41 ng/ml, 128.51+/-79.05 mg/l. The correlations for the NT-proBNP level and procalcitonin and C-reactive protein levels were 0.3273 (p<0.001) and 0.4134 (p<0.001), respectively. NT-proBNP levels correlate with PCT and CRP levels in septic patients. In the survivor subgroup, the mean NT-proBNP plasma concentrations were significantly lower than in the non-survivor subgroup.

PubMed Disclaimer

References

    1. Members of the American College of Chest Physicians/ Society of Crit Care Med Consensus Conference Committee American College of Chest Physicians/Society of Crit Care Med Consensus Conference: Definitions for sepsis and organ failure and guidelines for the use of innovative therapies in sepsis. Crit. Care Med. 1992;20:864–874. doi: 10.1097/00003246-199206000-00025. - DOI - PubMed
    1. Ugarte H., Silva E., Mercan D., De Mendonca A., Vincent J.L. Procalcitonin as a marker of infection in the intensive care unit. Crit. Care Med. 1999;27:498–504. doi: 10.1097/00003246-199903000-00024. - DOI - PubMed
    1. Wanner G.A., Keel M., Steckholzer U., Beier W., Stocker R., Ertel W. Relationship between procalcitonin plasma levels and severity of injury, sepsis, organ failure, and mortality in injured patients. Crit. Care Med. 2000;28:950–957. doi: 10.1097/00003246-200004000-00007. - DOI - PubMed
    1. Hoffmann U., Brueckmann M., Bertsch T., Wiessner M., Liebetrau C., Lang S., Haase K.K., Borggrefe M., Huhle G. Increased plasma levels of NT-proANP and NT-proBNP as markers of cardiac dysfunction in septic patients. Clin. Lab. 2005;51:373–379. - PubMed
    1. Castillo J.R., Zagler A., Carrillo-Jimenez R., Hennekens C.H. Brain natriuretic peptide: a potential marker for mortality in septic shock. Int. J. Infect. Dis. 2004;8:271–274. doi: 10.1016/j.ijid.2003.12.007. - DOI - PubMed