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. 2006:(50):1-2.
doi: 10.1093/nass/nrl001.

2'-Deoxy-4'-C-ethynyl-2-fluoroadenosine: a nucleoside reverse transcriptase inhibitor with highly potent activity against all HIV-1 strains, favorable toxic profiles and stability in plasma

Hiroshi Ohrui  1 , Satoru Kohgo, Hiroyuki Hayakawa, Eiichi Kodama, Masao Matsuoka, Tomohiro Nakata, Hiroyuki Mitsuya
Affiliations

2'-Deoxy-4'-C-ethynyl-2-fluoroadenosine: a nucleoside reverse transcriptase inhibitor with highly potent activity against all HIV-1 strains, favorable toxic profiles and stability in plasma

Hiroshi Ohrui et al. Nucleic Acids Symp Ser (Oxf). 2006.

Abstract

A working hypothesis to solve the critical problems of existing HAART was proposed. The study based on the hypothesis proved the validity of the hypothesis and resulted in the development of 2'-deoxy-4'-C-ethynyl-2-fluoro-adenosine (4'Ed2FA), a nucleoside reverse transcriptase inhibitor (NRTI) with highly potent activity against all HIV-1 strains, very favourable toxic profiles, and stability in plasma.

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