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. 2007 Jan;35(Database issue):D658-62.
doi: 10.1093/nar/gkl988. Epub 2006 Dec 6.

The Rat Genome Database, update 2007--easing the path from disease to data and back again

Simon N Twigger  1 , Mary Shimoyama, Susan Bromberg, Anne E Kwitek, Howard J Jacob; RGD Team
Affiliations

The Rat Genome Database, update 2007--easing the path from disease to data and back again

Simon N Twigger et al. Nucleic Acids Res. 2007 Jan.

Abstract

The Rat Genome Database (RGD, http://rgd.mcw.edu) is one of the core resources for rat genomics and recent developments have focused on providing support for disease-based research using the rat model. Recognizing the importance of the rat as a disease model we have employed targeted curation strategies to curate genes, QTL and strain data for neurological and cardiovascular disease areas. This work has centered on rat but also includes data for mouse and human to create 'disease portals' that provide a unified view of the genes, QTL and strain models for these diseases across the three species. The disease curation efforts combined with normal curation activities have served to greatly increase the content of the database, particularly for biological information, including gene ontology, disease, pathway and phenotype ontology annotations. In addition to improving the features and database content, community outreach has been expanded to demonstrate how investigators can leverage the resources at RGD to facilitate their research and to elicit suggestions and needs for future developments. We have published a number of papers that provide additional information on the ontology annotations and the tools at RGD for data mining and analysis to better enable researchers to fully utilize the database.

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Figures

Figure 1
Figure 1
Top search terms from the RGD web logs (June 1–July 4, 2006). The individual search terms are shown with the number of times that term was searched shown in parentheses. Font sizes are proportional to search frequency.
Figure 2
Figure 2
Screenshot of the RGD Neurological Disease portal showing the combined data for all neurological diseases. The various subsections of the page (A–D) are described in more detail in the text.
See this image and copyright information in PMC

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