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. 1991 Jul;82(7):755-7.
doi: 10.1111/j.1349-7006.1991.tb02698.x.

In vitro anti-human immunodeficiency virus type 1 activity of biliverdin, a bile pigment

H Mori  1 , T Otake, M Morimoto, N Ueba, N Kunita, T Nakagami, N Yamasaki, S Taji
Affiliations

In vitro anti-human immunodeficiency virus type 1 activity of biliverdin, a bile pigment

H Mori et al. Jpn J Cancer Res. 1991 Jul.

Abstract

Biliverdin (BV) is a bile pigment having anti-allergic properties. We examined the effect of BV on human immunodeficiency virus type 1 (HIV-1) in vitro. BV completely inhibited the cytopathic effect of HIV-1 in MT-4 cells at concentrations of 22.2 micrograms/ml or more. This inhibitory effect was also observed when BV was present during the adsorption period of HIV-1. However, BV was cytotoxic to MT-4 cells at concentrations above 800 micrograms/ml. At a concentration of 66.7 micrograms/ml, BV completely inhibited syncytia formation by HIV-infected and uninfected MOLT-4 cells. Moreover, after exposure of HIV-1 particles to BV for 2 h, the infectivity of the virus was reduced in a dose-dependent manner. It is speculated that the anti-HIV activity of BV is due to direct inactivation of virions and inhibition of virus binding to target cells.

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