Role of dissociation in "false drug allergy"

Abstract

Objective: The aim of the present study was to analyze the influence of dissociation on the "false allergy" phenomenon.

Method: Fifty-five individuals (11 males and 44 females) who consecutively presented for the study of their suspected drug allergy were assessed.

Results: After the challenge test, false allergy was found in 39.3% and placebo positive response in 12.5% of the patients. Seven patients (12.5%) scored above the cut-off point of 20 on the Dissociative Experiences Scale (DES), and 5 out of this group (71.4%) fit in the "false allergy" group. Pathological scores on the DES were associated with the diagnosis of "false allergy" (OR = 9.583, 95% CI = 1.002, 91.621). The effect of age, gender, and other psychopathological variables was controlled.

Conclusions: High levels of dissociation might predispose to false drug allergy, which could complicate pharmacological treatment and therefore increase the patient's complaints and demands for medical attention.