Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2007 Jan;57(1):40-8.
doi: 10.1111/j.1600-0897.2006.00443.x.

Could the defects in the endometrial extracellular matrix during the implantation be a cause for impaired fertility?

Jana Skrzypczak  1 , Przemysław Wirstlein, Mateusz Mikolajczyk
Affiliations

Could the defects in the endometrial extracellular matrix during the implantation be a cause for impaired fertility?

Jana Skrzypczak et al. Am J Reprod Immunol. 2007 Jan.

Abstract

Problem: Assessment of concentration of the metalloproteinase 9 (MMP9), tissue inhibitor of metalloproteinases 1 (TIMP1), urokinase plasminogen activator (uPA) and its receptor (uPAR) and leukaemia inhibitory factor (LIF) in the uterine fluid in women with idiopathic infertility and unknown cause for recurrent miscarriage.

Method of study: Uterine fluid obtained from patients with idiopathic infertility (n = 13), patients with unknown cause of recurrent miscarriages (n = 16) and healthy fertile women (n = 14). The assessment of MMP9, TIMP1, uPA, uPAR and LIF were performed with enzyme-linked immunosorbent assay.

Results: Statistically lower expression of MMP9 and TIMP1 in uterine fluid during implantation window in women with infertility and recurrent miscarriage of unknown cause.

Conclusion: Changed turnover of the extracellular matrix might be a cause of improper endometrial transition and in effect cause faulty implantation.

PubMed Disclaimer

LinkOut - more resources