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Review
. 2007 Feb;17(1):87-95.
doi: 10.1016/j.sbi.2006.11.003. Epub 2006 Dec 6.

Mechanisms of nucleic acid translocases: lessons from structural biology and single-molecule biophysics

Karl-Peter Hopfner  1 , Jens Michaelis
Affiliations
Review

Mechanisms of nucleic acid translocases: lessons from structural biology and single-molecule biophysics

Karl-Peter Hopfner et al. Curr Opin Struct Biol. 2007 Feb.

Abstract

Enzymes that translocate nucleic acids using ATP hydrolysis include DNA and RNA helicases, viral genome packaging motors and chromatin remodeling ATPases. Recent structural analysis, in conjunction with single-molecule studies, has revealed a wealth of new insights into how these enzymes use ATP-driven conformational changes to move on nucleic acids.

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