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Comment
. 2006 Dec;10(6):453-4.
doi: 10.1016/j.ccr.2006.11.007.

Integrated breast cancer genomics

Henrik Edgren  1 , Olli Kallioniemi
Affiliations
Free article
Comment

Integrated breast cancer genomics

Henrik Edgren et al. Cancer Cell. 2006 Dec.
Free article

Abstract

Predicting survival and therapy responses of breast cancer patients is a significant challenge. Two studies in this issue of Cancer Cell present a novel integrated analysis of genomic and transcriptomic profiles of 145 primary breast cancers and 51 established cell lines. Data from clinical tumors highlighted mechanisms of disease and facilitated identification of potential therapeutic targets and prognostic biomarkers. An extensive well-characterized cancer cell line resource opens up opportunities to explore the determinants of cellular responses to existing and emerging therapies. Taken together, these studies illustrate how integrated molecular profiling may one day significantly impact diagnosis and therapeutic choice in human breast cancer.

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  • A collection of breast cancer cell lines for the study of functionally distinct cancer subtypes.
    Neve RM, Chin K, Fridlyand J, Yeh J, Baehner FL, Fevr T, Clark L, Bayani N, Coppe JP, Tong F, Speed T, Spellman PT, DeVries S, Lapuk A, Wang NJ, Kuo WL, Stilwell JL, Pinkel D, Albertson DG, Waldman FM, McCormick F, Dickson RB, Johnson MD, Lippman M, Ethier S, Gazdar A, Gray JW. Neve RM, et al. Cancer Cell. 2006 Dec;10(6):515-27. doi: 10.1016/j.ccr.2006.10.008. Cancer Cell. 2006. PMID: 17157791 Free PMC article.
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