Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2006 Dec;10(6):454-6.
doi: 10.1016/j.ccr.2006.11.008.

Radiation resistance and stem-like cells in brain tumors

Dolores Hambardzumyan  1 , Massimo Squatrito, Eric C Holland
Affiliations
Free article

Radiation resistance and stem-like cells in brain tumors

Dolores Hambardzumyan et al. Cancer Cell. 2006 Dec.
Free article

Erratum in

  • Cancer Cell. 2007 Jan;11(1):97. Squartro, Massimo [corrected to Squatrito, Massimo]

Abstract

The concepts of stem cells being resistant to therapy, stem-like cells existing in brain tumors, and these tumors initially responding to therapy followed by recurrence are well documented. On this foundation, a recent paper in Nature has demonstrated that CD133-expressing glioma cells in vivo and in culture are relatively resistant to radiation. The mechanism of resistance involves the cell-cycle-regulating proteins CHK1/CHK2. The data raise many questions about the details of radiobiology of stem-like cells in their native environment within tumors in vivo. These answers may lead to better optimization of radiation treatments and schedules for these patients.

PubMed Disclaimer

LinkOut - more resources