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Comparative Study
. 2006 Dec 12;67(11):2063-5.
doi: 10.1212/01.wnl.0000247665.94088.8d.

High seroprevalence of Epstein-Barr virus in children with multiple sclerosis

D Pohl  1 , B Krone, K Rostasy, E Kahler, E Brunner, M Lehnert, H-J Wagner, J Gärtner, F Hanefeld
Affiliations
Comparative Study

High seroprevalence of Epstein-Barr virus in children with multiple sclerosis

D Pohl et al. Neurology. .

Abstract

We studied seroprevalence and concentrations of Epstein-Barr virus (EBV) antibodies in 147 pediatric patients with multiple sclerosis (MS) and paired controls. The children with MS showed a near-complete seropositivity for EBV antibody against virus capsid antigen (98.6% vs 72.1% in controls, p = 0.001) but did not display serologic evidence for a recent EBV infection. EBV antibody concentrations of pediatric patients with MS were significantly higher vs controls.

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