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Review
. 2007 Feb;6(2):115-20.
doi: 10.1038/nrd2155. Epub 2006 Dec 8.

Why is cancer drug discovery so difficult?

Alexander Kamb  1 , Susan Wee, Christoph Lengauer
Affiliations
Review

Why is cancer drug discovery so difficult?

Alexander Kamb et al. Nat Rev Drug Discov. 2007 Feb.

Abstract

Thirty-five years after the 'war on cancer' was declared, the discovery of anticancer drugs remains a highly challenging endeavour. Here, we consider the factors responsible, such as tumour heterogeneity, and suggest strategies to improve the chances of short-term success in the development of novel anticancer drugs.

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