Review
doi: 10.1016/0166-2236(91)90121-a.
The neurobiology of narcolepsy
Affiliations
- PMID: 1716016
- DOI: 10.1016/0166-2236(91)90121-a
Item in Clipboard
Review
The neurobiology of narcolepsy
Trends Neurosci.
1991 Jun.
Free article
Abstract
Narcolepsy is characterized by excessive sleepiness and abnormal manifestations of rapid eye movement (REM) sleep. Neurochemical studies of human and canine narcolepsy have demonstrated disturbed monoaminergic and cholinergic function and suggest that deficits of noradrenaline availability in specific brain regions may account for much of its disordered pathophysiology. Genetic susceptibility to narcolepsy is closely linked to a specific region of the major histocompatibility complex on chromosome 6 and an important direction for future research will be to unravel the relationship between this gene region and the neurochemical abnormalities of narcolepsy.
Similar articles
-
The neurobiology of narcolepsy-cataplexy syndrome.Int J Neurol. 1991-1992;25-26:29-40. Int J Neurol. 1991. PMID: 11980061 Review.
-
Narcolepsy.Neurology. 1992 Jul;42(7 Suppl 6):34-43. Neurology. 1992. PMID: 1630637 Review.
-
Perspectives in narcolepsy research and therapy.Curr Opin Pulm Med. 1996 Nov;2(6):482-7. Curr Opin Pulm Med. 1996. PMID: 9363189 Review.
-
Heterozygosity at the canarc-1 locus can confer susceptibility for narcolepsy: induction of cataplexy in heterozygous asymptomatic dogs after administration of a combination of drugs acting on monoaminergic and cholinergic systems.J Neurosci. 1993 Mar;13(3):1057-64. doi: 10.1523/JNEUROSCI.13-03-01057.1993. J Neurosci. 1993. PMID: 8095066 Free PMC article.
-
A perspective on narcolepsy.Encephale. 1992 Jul-Aug;18(4):347-51. Encephale. 1992. PMID: 1338429
Cited by
-
To be or not to be hallucinating: Implications of hypnagogic/hypnopompic experiences and lucid dreaming for brain disorders.PNAS Nexus. 2023 Dec 19;3(1):pgad442. doi: 10.1093/pnasnexus/pgad442. eCollection 2024 Jan. PNAS Nexus. 2023. PMID: 38178978 Free PMC article.
-
Hypocretin-2-saporin lesions of the lateral hypothalamus produce narcoleptic-like sleep behavior in the rat.J Neurosci. 2001 Sep 15;21(18):7273-83. doi: 10.1523/JNEUROSCI.21-18-07273.2001. J Neurosci. 2001. PMID: 11549737 Free PMC article.
-
Rewiring brain circuits to block cataplexy in murine models of narcolepsy.Curr Opin Neurobiol. 2017 Jun;44:110-115. doi: 10.1016/j.conb.2017.03.017. Epub 2017 Apr 23. Curr Opin Neurobiol. 2017. PMID: 28445807 Free PMC article. Review.
-
Neurons containing orexin or melanin concentrating hormone reciprocally regulate wake and sleep.Front Syst Neurosci. 2015 Jan 8;8:244. doi: 10.3389/fnsys.2014.00244. eCollection 2014. Front Syst Neurosci. 2015. PMID: 25620917 Free PMC article. Review.
-
Neuronal degeneration in canine narcolepsy.J Neurosci. 1999 Jan 1;19(1):248-57. doi: 10.1523/JNEUROSCI.19-01-00248.1999. J Neurosci. 1999. PMID: 9870955 Free PMC article.
Publication types
MeSH terms
LinkOut - more resources
Full Text Sources
Other Literature Sources
