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Case Reports
. 2007 May;34(4):200-2.
doi: 10.1055/s-2006-940050. Epub 2006 Dec 7.

[Rofecoxib-induced psychosis]

[Article in German]
Michael Sabolek  1 , Alexander Unrath, Anne-Dorte Sperfeld, Bernhard J Connemann, Jan Kassubek
Affiliations
Case Reports

[Rofecoxib-induced psychosis]

[Article in German]
Michael Sabolek et al. Psychiatr Prax. 2007 May.

Abstract

Acute psychosis is a possible side effect of many centrally acting drugs. Its appearance is facilitated by certain conditions like advanced age, comedication, or comorbidity. We report two cases of acute psychotic syndromes with visual (Case 1 + 2) and auditory (Case 1) hallucinations under rofecoxib, a cyclooxygenase-2-inhibitor. This is one of the first reports of psychotic disorders under rofecoxib intake. We present a review of the literature on mental side effects of NSAID and on the pharmacological basis of the association of cyclooxygenase-inhibitors and mental disorders.

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