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Review
. 2008 Jan;28(1):1-38.
doi: 10.1002/med.20096.

Anti-influenza virus agents: synthesis and mode of action

Irene M Lagoja  1 , Erik De Clercq
Affiliations
Review

Anti-influenza virus agents: synthesis and mode of action

Irene M Lagoja et al. Med Res Rev. 2008 Jan.

Abstract

Annual epidemics of influenza virus infection are responsible for considerable morbidity and mortality, and pandemics are much more devastating. Considerable knowledge of viral infectivity and replication has been acquired, but many details still have to be elucidated and the virus remains a challenging target for drug design and development. This review provides an overview of the antiviral drugs targeting the influenza viral replicative cycle. Included are a brief description of their chemical syntheses and biological activities. For other reviews, see References1-9.

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References

    1. Roberts NA. Anti‐influenza drugs and neuraminidase inhibitors. Progress Drug Res 2001; 56: 195–237. - PubMed
    1. Shigeta S. Targets of anti‐influenza chemotherapy other than neuraminidase and proton pump. Antiviral Chem Chemother 2001; 12: 179–188. - PubMed
    1. Schmidt AC. Antiviral therapy for influenza. A clinical and economic comparative review. Drugs 2004; 64(18): 2031–2046. - PubMed
    1. Monto AS. The role of antivirals in the control of influenza. Vaccine 2003; 21: 1796–1800. - PubMed
    1. De Clercq E. Highlights in the development of new antiviral agents. Mini Rev Med Chem 2002; 2: 163–175. - PubMed

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