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. 2006 Dec;14(12):1767-77.
doi: 10.1016/j.str.2006.10.003.

Stability and dynamics of virus capsids described by coarse-grained modeling

Anton Arkhipov  1 , Lydia Freddolino, Klaus Schulten
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Free article

Stability and dynamics of virus capsids described by coarse-grained modeling

Anton Arkhipov et al. Structure. 2006 Dec.
Free article

Abstract

We report a study of the structural dynamics of viral capsids, simulated on a microsecond timescale, by employing a coarse-graining molecular dynamics method. The method was calibrated against an all-atom simulation of one complete virus. Among the studied capsids, some collapsed rapidly, while others were found to be stable. Interlocking between coat proteins is found to be a key factor determining the stability of the capsids.

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