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Review
. 2007 Feb;18(1):117-31.
doi: 10.1016/j.semcdb.2006.11.012. Epub 2006 Nov 24.

Re-employment of developmental transcription factors in adult heart disease

Toru Oka  1 , Jian Xu, Jeffery D Molkentin
Affiliations
Review

Re-employment of developmental transcription factors in adult heart disease

Toru Oka et al. Semin Cell Dev Biol. 2007 Feb.

Abstract

A finite number of transcription factors constitute a combinatorial code that orchestrates cardiac development and the specification and differentiation of myocytes. Many, if not all of these same transcription factors are re-employed in the adult heart in response to disease stimuli that promote hypertrophic enlargement and/or dilated cardiomyopathy, as part of the so-called "fetal gene program". This review will discuss the transcription factors that regulate the hypertrophic growth response of the adult heart, with a special emphasis on those regulators that participate in cardiac development.

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