Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2006 Jun-Dec;13(2-4):101-7.
doi: 10.1080/17402520600877182.

NK cells and type 1 diabetes

Melanie Rodacki  1 , Adolpho Milech, José Egídio Paulo de Oliveira
Affiliations
Review

NK cells and type 1 diabetes

Melanie Rodacki et al. Clin Dev Immunol. 2006 Jun-Dec.

Abstract

Type 1 diabetes (T1D) is characterized by an immuno-mediated progressive destruction of the pancreatic beta cells. Due to the ability of NK cells to kill target cells as well as to interact with antigen-presenting and T cells, it has been suggested that they could be involved in one or multiple steps of the immune-mediated attack that leads to T1D. Abnormalities in the frequency and activity of NK cells have been described both in animal models and patients with T1D. Some of these alterations are linked to its onset while others seem to be a consequence of the disease. Here, we discuss the main characteristics of NK cells and review the studies that investigated the role of NK cells in T1D, both in mouse models and humans.

PubMed Disclaimer

MeSH terms