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Review
. 2006 Jun 20;1(5):279-84.
doi: 10.1021/cb600224w.

Tumor selectivity of Hsp90 inhibitors: the explanation remains elusive

Gabriela Chiosis  1 , Len Neckers
Affiliations
Review

Tumor selectivity of Hsp90 inhibitors: the explanation remains elusive

Gabriela Chiosis et al. ACS Chem Biol. .

Abstract

Two recent papers attempt to solve both the tumor selectivity and the in vivo tumor accumulation profiles seen with some Hsp90 inhibitors. They spotlight the higher affinity of ansamycins' hydroquinone over the quinone form for Hsp90 and further discuss its possible contribution to ansamycins' tumor selectivity.

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