doi: 10.1039/b613775j.
Epub 2006 Nov 6.
A highly effective one-pot synthesis of quinolines from o-nitroarylcarbaldehydes
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- PMID: 17164907
- DOI: 10.1039/b613775j
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A highly effective one-pot synthesis of quinolines from o-nitroarylcarbaldehydes
Org Biomol Chem.
.
Abstract
A highly effective one-pot Friedländer quinoline synthesis using inexpensive reagents has been developed. o-Nitroarylcarbaldehydes were reduced to o-aminoarylcarbaldehydes with iron in the presence of catalytic HCl (aq.) and subsequently condensed in situ with aldehydes or ketones to form mono- or di-substituted quinolines in high yields (66-100%).
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