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. 2007 Jan 7;5(1):61-4.
doi: 10.1039/b613775j. Epub 2006 Nov 6.

A highly effective one-pot synthesis of quinolines from o-nitroarylcarbaldehydes

An-Hu Li  1 , Eilaf Ahmed, Xin Chen, Matthew Cox, Andrew P Crew, Han-Qing Dong, Meizhong Jin, Lifu Ma, Bijoy Panicker, Kam W Siu, Arno G Steinig, Kathryn M Stolz, Paula A R Tavares, Brian Volk, Qinghua Weng, Doug Werner, Mark J Mulvihill
Affiliations

A highly effective one-pot synthesis of quinolines from o-nitroarylcarbaldehydes

An-Hu Li et al. Org Biomol Chem. .

Abstract

A highly effective one-pot Friedländer quinoline synthesis using inexpensive reagents has been developed. o-Nitroarylcarbaldehydes were reduced to o-aminoarylcarbaldehydes with iron in the presence of catalytic HCl (aq.) and subsequently condensed in situ with aldehydes or ketones to form mono- or di-substituted quinolines in high yields (66-100%).

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