Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 1975 Aug;72(8):3124-8.
doi: 10.1073/pnas.72.8.3124.

Human synoviocytes: activation and desensitization by prostaglandins and 1-epinephrine

D S Newcombe, C P Ciosek Jr, Y Ishikawa, J V Fahey

Human synoviocytes: activation and desensitization by prostaglandins and 1-epinephrine

D S Newcombe et al. Proc Natl Acad Sci U S A. 1975 Aug.

Abstract

The human synoviocyte increases its intracellular adenosine 3':5'-cyclic monophosphate (cAMP) concentration significantly after incubation with prostaglandin E1, prostaglandin E2, or l-epinephrine. The cells can be desensitized to these same hormones. Hormone-induced desensitization is receptor site specific and associated with a significant increase in intracellular 3':5'-cyclic AMP phosphodiesterase (EC 3.1.4. 17; 3':5'-cyclic AMP 5'-nucleotidohydrolase) activity, whereas cAMP-induced desensitization is not hormone specific.

PubMed Disclaimer

Similar articles

See all similar articles

Cited by

See all "Cited by" articles

References

    1. J Biol Chem. 1951 Nov;193(1):265-75 - PubMed
    1. Proc Natl Acad Sci U S A. 1974 Oct;71(10):3844-8 - PubMed
    1. Proc Natl Acad Sci U S A. 1970 Sep;67(1):305-12 - PubMed
    1. Biochemistry. 1971 Jan 19;10(2):311-6 - PubMed
    1. Biochem J. 1970 Nov;120(1):187-93 - PubMed

Publication types