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. 1975 Aug;72(8):3124-8.
doi: 10.1073/pnas.72.8.3124.

Human synoviocytes: activation and desensitization by prostaglandins and 1-epinephrine

D S Newcombe, C P Ciosek Jr, Y Ishikawa, J V Fahey

Human synoviocytes: activation and desensitization by prostaglandins and 1-epinephrine

D S Newcombe et al. Proc Natl Acad Sci U S A. 1975 Aug.

Abstract

The human synoviocyte increases its intracellular adenosine 3':5'-cyclic monophosphate (cAMP) concentration significantly after incubation with prostaglandin E1, prostaglandin E2, or l-epinephrine. The cells can be desensitized to these same hormones. Hormone-induced desensitization is receptor site specific and associated with a significant increase in intracellular 3':5'-cyclic AMP phosphodiesterase (EC 3.1.4. 17; 3':5'-cyclic AMP 5'-nucleotidohydrolase) activity, whereas cAMP-induced desensitization is not hormone specific.

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