Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 1975 Aug;72(8):3206-9.
doi: 10.1073/pnas.72.8.3206.

Enhanced representation of HL-A antigens on human lymphocytes after mitogenesis induced by phytohemagglutinin or Epstein-Barr virus

J M McCune, R E Humphreys, R R Yocum, J L Strominger

Enhanced representation of HL-A antigens on human lymphocytes after mitogenesis induced by phytohemagglutinin or Epstein-Barr virus

J M McCune et al. Proc Natl Acad Sci U S A. 1975 Aug.

Abstract

The amount of HL-A antigens present on the peripheral blood lymphocytes of a single human donor was increased about 11-fold after stimulation with phytohemagglutinin and 36-fold after transformation with Epstein-Barr virus. This increase applied to all four HL-A specificities of these cells. The response to phytohemagglutinin was dependent on dose and was first observed at 12 hr of incubation. Measurements of the amount of surface membranes by geometry, by radioiodinatable surface proteins, and by 5'-nucleotidase (5'-ribonucleotide phosphohydrolase, EC 3.1.3.5) assay all indicated that the enhanced representation of HL-A antigens after stimulation by phytohemagglutinin or transformation by Epstein-Barr virus must be due to an increase in the density of these antigens on the cell surface.

PubMed Disclaimer

References

    1. J Immunol. 1975 May;114(5):1532-6 - PubMed
    1. Lancet. 1971 Apr 24;1(7704):852-3 - PubMed
    1. Transplantation. 1972 Mar;13(3):250-5 - PubMed
    1. J Immunol. 1972 Feb;108(2):573-6 - PubMed
    1. Immunology. 1973 Feb;24(2):315-31 - PubMed

Publication types

MeSH terms