doi: 10.1073/pnas.72.9.3347.
Identification of the 5' end of Rous sarcoma virus RNA
- PMID: 171660
- PMCID: PMC432989
- DOI: 10.1073/pnas.72.9.3347
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Identification of the 5' end of Rous sarcoma virus RNA
Proc Natl Acad Sci U S A.
1975 Sep.
Abstract
The 5'-terminal triphosphate of the 35S RNA isolated from Rous sarcoma virus is blocked by 7-methylguanosine in 5' linkage with the penultimate nucleoside which is methylated in the 2'-O-ribose position, a type of endgroup found in all animal mRNAs investigated during the past year. The specific nuclease-resistant terminal fragment of RSV RNA has the structure 7mG5'ppp5'GmpCp-. This finding supports the belief that RNA of Rous sarcoma virus represents a (+) strand messenger which may be directly translated upon infection.
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