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. 1991 Oct;59(10):3846-8.
doi: 10.1128/iai.59.10.3846-3848.1991.

Prevention of murine cerebral malaria by a stable prostacyclin analog

K Sliwa  1 , H J Grundmann, S Neifer, M F Chaves, G Sahlmüller, E Blitstein-Willinger, U Bienzle, P G Kremsner
Affiliations

Prevention of murine cerebral malaria by a stable prostacyclin analog

K Sliwa et al. Infect Immun. 1991 Oct.

Abstract

Iloprost, a synthetic prostacyclin analog, successfully prevents the development of cerebral malaria in mice. Malaria antigen-induced tumor necrosis factor (TNF) production could be inhibited by iloprost in vitro and in vivo. Northern analysis of TNF mRNA revealed that malaria antigen-induced TNF expression was suppressed at the transcription level.

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