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. 2007 Jun;91(6):737-8.
doi: 10.1136/bjo.2006.109843. Epub 2006 Dec 13.

Positive correlation between pigment epithelium-derived factor and monocyte chemoattractant protein-1 levels in the aqueous humour of patients with uveitis

Yumiko Yoshida  1 , Sho-Ichi Yamagishi, Takanori Matsui, Kazuo Nakamura, Tsutomu Imaizumi, Koichi Yoshimura, Ryoji Yamakawa
Affiliations

Positive correlation between pigment epithelium-derived factor and monocyte chemoattractant protein-1 levels in the aqueous humour of patients with uveitis

Yumiko Yoshida et al. Br J Ophthalmol. 2007 Jun.

Abstract

Aim: To evaluate whether aqueous humour levels of pigment epithelium-derived factor (PEDF) are associated with monocyte chemoattractant protein-1 (MCP-1) in patients with uveitis.

Methods: Aqueous humour levels of MCP-1 and PEDF were determined by ELISA in 34 uveitis samples and 9 cataract control samples.

Results: Aqueous humour MCP-1 and PEDF levels were significantly higher in patients with infectious or non-infectious uveitis than in controls (mean (SD) 32.3 (10.7) ng/ml vs 4.48 (1.10) ng/ml vs 0.47 (0.10) ng/ml, and 8.40 (1.30) microg/ml vs 5.01 (0.92) microg/ml vs 1.32 (0.22) microg/ml, respectively, p<0.001). A positive correlation between PEDF and MCP-1 was found in patients with uveitis (r = 0.39, p<0.01).

Conclusion: The results demonstrated that aqueous humour levels of PEDF were positively associated with MCP-1 in patients with uveitis. The present observations suggest that aqueous humour levels of PEDF may be a marker of inflammation in uveitis.

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Conflict of interest statement

Competing interests: None declared.

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