Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 1991 Sep 15;88(18):7938-42.
doi: 10.1073/pnas.88.18.7938.

Light-dependent channels from excised patches of Limulus ventral photoreceptors are opened by cGMP

J Bacigalupo  1 , E C Johnson, C Vergara, J E Lisman
Affiliations

Light-dependent channels from excised patches of Limulus ventral photoreceptors are opened by cGMP

J Bacigalupo et al. Proc Natl Acad Sci U S A. .

Abstract

The identity of the second messenger that directly activates the light-dependent conductance in invertebrate photoreceptors remains unclear; the available evidence provides some support for cGMP and Ca2+. To resolve this issue we have applied these second messengers to membrane patches excised from the light-sensitive lobe of Limulus ventral photoreceptors. Our results show that these patches contain channels that can be opened by cGMP, but not by Ca2+. These cGMP-activated channels closely resemble the channels activated by light in cell-attached patches. This evidence suggests that cGMP is the messenger that opens the light-dependent channel in invertebrate photoreceptors.

PubMed Disclaimer

Similar articles

See all similar articles

Cited by

See all "Cited by" articles

References

    1. Vis Neurosci. 1989 Jul;3(1):1-7 - PubMed
    1. J Gen Physiol. 1991 Jun;97(6):1187-205 - PubMed
    1. Proc Natl Acad Sci U S A. 1987 Oct;84(19):6939-43 - PubMed
    1. Proc Natl Acad Sci U S A. 1985 Dec;82(24):8813-7 - PubMed
    1. Proc Natl Acad Sci U S A. 1987 Jan;84(1):299-302 - PubMed

Publication types

LinkOut - more resources