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. 1991 Sep 15;88(18):7938-42.
doi: 10.1073/pnas.88.18.7938.

Light-dependent channels from excised patches of Limulus ventral photoreceptors are opened by cGMP

J Bacigalupo  1 , E C Johnson, C Vergara, J E Lisman
Affiliations

Light-dependent channels from excised patches of Limulus ventral photoreceptors are opened by cGMP

J Bacigalupo et al. Proc Natl Acad Sci U S A. .

Abstract

The identity of the second messenger that directly activates the light-dependent conductance in invertebrate photoreceptors remains unclear; the available evidence provides some support for cGMP and Ca2+. To resolve this issue we have applied these second messengers to membrane patches excised from the light-sensitive lobe of Limulus ventral photoreceptors. Our results show that these patches contain channels that can be opened by cGMP, but not by Ca2+. These cGMP-activated channels closely resemble the channels activated by light in cell-attached patches. This evidence suggests that cGMP is the messenger that opens the light-dependent channel in invertebrate photoreceptors.

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