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Comparative Study
. 1991 May;33(1-2):124-5.
doi: 10.1007/BF01993144.

Patterns of histamine release in the brain

A Philippu  1 , H Prast
Affiliations
Comparative Study

Patterns of histamine release in the brain

A Philippu et al. Agents Actions. 1991 May.

Abstract

The pattern of histamine release has been investigated in various brain areas of anaesthetized cats and conscious, freely moving rats by the push-pull technique. In the hypothalamus, medial amygdaloid nucleus and mamillary body of the anaesthetized cat, histamine was found to be released according to an ultradian rhythm with a frequency of 1 cycle per 1-2 h. Additionally, oscillations have been observed in the medial amygdaloid nucleus and mamillary body with a frequency of 1 oscillation per 10 min. In the posterior hypothalamus of the conscious rat, histamine is also released rhythmically with a frequency of 1 cycle per 1.5 h. Moreover, the release rate of histamine is increased in the night.

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