doi: 10.1007/BF01993121.
Effect of chloroquine on isolated mast cells
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- PMID: 1716835
- DOI: 10.1007/BF01993121
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Effect of chloroquine on isolated mast cells
Agents Actions.
1991 May.
Abstract
Chloroquine liberated a relatively low amount of histamine from isolated rat mast cells. In a dose-dependent way, this drug inhibited histamine liberation from mast cells stimulated with compound 48/80, A23187, concanavalin A plus phosphatidylserine (Con A + PS) and abolished histamine liberation induced by exaprolol. The degranulation was decreased in cells stimulated with 48/80, Con A + PS and exaprolol. Chloroquine significantly inhibited the formation of thromboxane B2 in mast cells stimulated with 48/80, Con A + PS and A23187. We assume that chloroquine interferes with mast cells at a plasmic membrane site as well as intracellularly.
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