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. 1991 Sep 16;179(2):713-9.
doi: 10.1016/0006-291x(91)91875-d.

Adhesion of human cancer cells to vascular endothelium mediated by a carbohydrate antigen, sialyl Lewis A

A Takada  1 , K Ohmori, N Takahashi, K Tsuyuoka, A Yago, K Zenita, A Hasegawa, R Kannagi
Affiliations

Adhesion of human cancer cells to vascular endothelium mediated by a carbohydrate antigen, sialyl Lewis A

A Takada et al. Biochem Biophys Res Commun. .

Abstract

Recently the lectin-like domain on ELAM-1 (endothelial leukocyte adhesion molecule-1) was shown to recognize a carbohydrate antigen, sialyl Lewis x. In this paper we demonstrate, by a series of inhibition experiments utilizing specific monoclonal antibodies and pure glycolipid preparations, that the sialyl Lewis a antigen serves as a specific ligand for ELAM-1 as well as sialyl Lewis x and plays a significant role in the ELAM-1-mediated binding of human cancer cells to activated endothelial cells.

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